Accession Number : ADA010820


Title :   Aseptic Endotoxemia in Radiation Injury and Graft Versus Host Disease


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Walker, R. I. ; Ledney, G. D. ; Galley, C. B.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA010820


Report Date : FEB 1975


Pagination or Media Count : 20


Abstract : Endotoxemia of intestinal origin may impair physiologic and immunologic functions in individuals subjected to high doses of either ionizing radiation or radiation followed by transplants of foreign immune competent cells capable of producing graft versus host disease (GVHD). The results of the following studies support the contention that aseptic endotoxemia may be due to failure to clear endotoxin from the circulation and detoxify it in the liver of immunosuppressed animals.


Descriptors :   *IMMUNOSUPPRESSION, *ENDOTOXINS, *RADIATION INJURIES, IMMUNOLOGY, SEPSIS, PHAGOCYTES, SURGICAL TRANSPLANTATION, RADIOBIOLOGY


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE