Accession Number : ADA010141


Title :   An 'in vivo' Model for the Definitive Analysis of Cellular Inflammation in Normal and Irradiated Rats


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Wyant, D. E. ; Baum, S. J.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA010141


Report Date : DEC 1974


Pagination or Media Count : 18


Abstract : A new in vivo model which gives a more accurate picture of cellular inflammation was developed. It involves a subcutaneously implanted plastic cup which can easily be used to assess quantitatively dynamic exudate cell migration. The use of this model in normal and irradiated rats has provided new insights into the kinetics of exudate cells during acute inflammation. Under the conditions described in this study, it appears that mononuclear cells are the dominant type cells in inflammatory exudates much earlier than has been previously reported in studies using less quantitative models.


Descriptors :   *LEUKOCYTES, *INFLAMMATION, *CELLS(BIOLOGY), RADIATION EFFECTS, RESPONSE(BIOLOGY), KINETICS, MODELS, IN VIVO ANALYSIS


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE