Accession Number : ADA010141
Title : An 'in vivo' Model for the Definitive Analysis of Cellular Inflammation in Normal and Irradiated Rats
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Wyant, D E ; Baum, S J
Report Date : Dec 1974
Pagination or Media Count : 18
Abstract : A new in vivo model which gives a more accurate picture of cellular inflammation was developed. It involves a subcutaneously implanted plastic cup which can easily be used to assess quantitatively dynamic exudate cell migration. The use of this model in normal and irradiated rats has provided new insights into the kinetics of exudate cells during acute inflammation. Under the conditions described in this study, it appears that mononuclear cells are the dominant type cells in inflammatory exudates much earlier than has been previously reported in studies using less quantitative models.
Descriptors : *LEUKOCYTES , *INFLAMMATION , *CELLS(BIOLOGY) , RADIATION EFFECTS , RESPONSE(BIOLOGY) , KINETICS , MODELS , IN VIVO ANALYSIS
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE