Accession Number : ADA006791


Title :   Hemopoietic Stem Cell Migration in Mice of Genotype S1/S1d Following a Single Injection of Bordetella pertussis Vaccine.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : McCarthy,K. F. ; MacVittie,T. J.


Report Date : NOV 1974


Pagination or Media Count : 16


Abstract : The ability of a single injection of Bordetella pertussis vaccine to cause an increase in the number of circulating transplantable colony forming units (CFU) in mice of genotype S1/S1d and their normal congeneric littermates was studied. Seventy-six hours after injection of B. pertussis vaccine, the number of circulating CFU per milliliter of blood in normal mice increased from approximately 45 CFU/ml to over 300 CFU/ml, while in S1/S1d mice the number of circulating CFU increased from approximately 22 CFU/ml to only 57 CFU/ml. Thus, the previously reported restriction of splenic CFU growth in S1/S1d mice following multiple injections of endotoxin is discussed in the present work not only in terms of a defect in splenic stromal elements necessary for maximum CFU growth, but also in view of current concepts of CFU migration from marrow to spleen via the circulation.


Descriptors :   *MUTATIONS, *HEMATOPOIETIC CELLS, EXPERIMENTAL DATA, STRESS(PHYSIOLOGY), MICE, GENETICS, BONE MARROW, VACCINES, ENDOTOXINS, SPLEEN, GROWTH(PHYSIOLOGY), BORDETELLA PERTUSSIS.


Subject Categories : ANATOMY AND PHYSIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE