Accession Number : ADA005764


Title :   The Effect of Dexamethasone on the Formation Rate of Cerebrospinal Fluid in Monkeys,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Martins,A. N. ; Ramirez,A. ; Solomon,L. S. ; Wiese,G. M.


Report Date : SEP 1974


Pagination or Media Count : 15


Abstract : A standard ventriculocisternal perfusion technique was used to determine what effect a single large intravenous dose of dexamethasone would have on cerebrospinal fluid (CSF) formation rate in the rhesus monkey over a 4-hour period. Three monkeys received 0.15 mg/kg, four received 0.4 mg/kg and five served as untreated controls. With time, CSF formation rates decreased in both treated and control groups. The magnitude of the decrease in the treated and the untreated controls did not differ significantly, and it is concluded that the therapeutic benefit of dexamethasone for intracranial spatial decompensation derives from a mechanism of action that leaves the rate of CSF formation unchanged.


Descriptors :   *STEROIDS, *CEREBROSPINAL FLUID, BRAIN, DOSAGE, NEUROLOGY, CHEMOTHERAPY, EDEMA.


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE