Accession Number : ADA004195


Title :   An EEG Study of Morphine Tolerance in the Rat.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Teitelbaum,H. ; Catravas,G. N. ; McFarland,W. L.


Report Date : AUG 1974


Pagination or Media Count : 15


Abstract : Tolerance, manifested by a diminished EEG response at cortical and subcortical recording sites, was found in rats subjected to repeated systemic injections of morphine sulfate. Reversal of tolerance to morphine resulted from destruction of the medial thalamus.


Descriptors :   *DRUG ADDICTION, *MORPHINE, EXPERIMENTAL DATA, BRAIN, RATS, DRUGS, CENTRAL NERVOUS SYSTEM, TOLERANCES(PHYSIOLOGY), ELECTROENCEPHALOGRAPHY, CEREBRAL CORTEX, THALAMUS.


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE