Accession Number : ADA000961


Title :   Sequential Changes of Vascular Ultrastructure in Cerebral Vasospasm: Myonecrosis of Subarachnoid Arteries.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Fein,J. M. ; Flor,W. J. ; Parkhurst,L. J. ; Parker,J. L.


Report Date : JUN 1974


Pagination or Media Count : 23


Abstract : Cerebral vasospasm following subarachnoid hemorrhage may contribute to morbidity and mortality. The inconsistent therapeutic responses to sympatholytic agents described in the literature raise doubts as to the purely functional nature of the vasoconstriction. This study examines the ultrastructural evolution of vascuolar degeneration of the media in subarachnoid arteries which have been in spasm. The striking changes of myoarchitecture are described; however, the relationship of these findings to aberrations in cerebral blood flow remains to be clarified. (Author)


Descriptors :   *HEMORRHAGE, *CONVULSIVE DISORDERS, *CEREBROVASCULAR SYSTEM, BRAIN, PATHOLOGY, NEUROLOGY, BLOOD CIRCULATION, HISTOLOGY, ARTERIES, CEREBRUM, VASOCONSTRICTING, SYMPATHOLYTIC AGENTS.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE