Accession Number : AD1048789


Title :   Characterizing the Role of Hep27 in Liver and Colorectal Cancer Stress Tolerance


Descriptive Note : Technical Report,15 Sep 2016,14 Sep 2017


Corporate Author : University of North Carolina at Chapel Hill Chapel Hill United States


Personal Author(s) : Tackmann, Nicole


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1048789.pdf


Report Date : 01 Jan 2018


Pagination or Media Count : 15


Abstract : This project seeks to characterize a potentially novel ROS responding protein that may be especially important in colorectal and liver cancer cells. This protein, Hep27, is overexpressed in hepatocellular carcinoma, and its high expression correlates with decreased survival in colon cancers. It was hypothesized that Hep27 overexpression is a mechanism of resistance to cancer therapies by increasing ROS tolerance in colorectal and liver cancers through its enzymatic activity. This project proposed to use human cell lines to test whether modulation of Hep27 expression contributes to cell ROS tolerance and survival. Thus far, the work on this project has not demonstrated that Hep27 plays a role in ROS tolerance in liver cancer cells.


Descriptors :   colon cancer , stress (physiology) , proteins , cell line , carcinoma , apoptosis , deoxyribonucleic acids


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE