Accession Number : AD1048749


Title :   Optical Elastography of Systemic Sclerosis Skin


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : University of Houston Houston United States


Personal Author(s) : Mohan, Chandra ; Larin,Kirill ; Assassi,Shervin


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1048749.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 15


Abstract : Excessive accumulation of collagen and skin-thickening are hallmark features of Systemic sclerosis (SSc). The subjectiveness and the lack of precision associated with the Rodnan skin score, the current gold standard, calls for an improved detection method. Technologies such as magnetic resonance imaging, ultrasound, and optical coherence tomography have been tested in SSc, with varying success. Here, we advance a novel contact-independent noninvasive technique capable of micrometer/nanometer spatial resolution called optical coherence elastography (OCE) for monitoring skin disease in SSc. We have established the feasibility of using this technology to identify elasticity changes caused by SSc in vivo in murine skin. For the proposed human studies in Aim 2, the assessment of mRSS score and the OCE examination has been completed in 2participants (one patient with limited systemic sclerosis and one age-, race-, and gender-matched control). The generated raw data have been analyzed and shows promising preliminary results. We have been actively screening our clinic patients for additional participants. Four additional participants have been scheduled to participate in this study in December 2017. For the proposed murine studies in Aim 1, the animal model of SSc has been successfully re-established. In addition, animals are being scheduled for the proposed treatment and monitoring study.


Descriptors :   sclerosis , imaging techniques , diagnostic imaging , diagnosis (medicine) , tomography , skin , thickness , elastic properties , Histopathology


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE