Accession Number : AD1048531


Title :   Theranostics Targeting Metastatic Breast Cancer


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Methodist Hospital Houston United States


Personal Author(s) : Li, Zheng


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1048531.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 21


Abstract : The emphasis of this first year of the award, as planned, has been on synthetic chemistry to obtain materials to test in histology, PET (positron emission tomography) and PDT(photodynamic therapy) studies. We have been successful in preparing samples for the testing studies that begin in year 2. However, as anticipated, the synthetic chemistry work was not without problems and must continue and adapt to overcome challenges that now become evident. For instance, one of the molecules first prioritized, compound 1, was prepared, but only after a great deal of effort; in retrospect it is now clear that this compound has stability issues that make it hard to make, and inappropriate for further studies. Another target compound (2) was then prepared, much more efficiently than the first because it does not have stability issues, and because of the experience we gained from making the first target. This compound has poor solubility characteristics despite the fact that it contains two sulfonic acid groups and may required delivery in micelles; this is something that could not have been predicted until the compound was made. Both structures 1 and 2 are based on the aza-BODIPY dye fragment; as a back-up we have also initiated work on a compound based on a different-dye type, eg compound 3. The original proposal outlined plans to add cytotoxic entities other than PDT agents; for this we entered into a collaboration with a biotechnology company who have provided us a small sample of the previous, highly cytotoxic, compound may tensin A. We have also prepared an agent intended solely for PET, ie compound 4; this takes advantage of very recent advances in the field that enable more efficient capture of 18F- than was possible before, via so-called Perrin capture agents.


Descriptors :   breast cancer , therapy , metastasis , histology , positron emission tomography


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE