Accession Number : AD1045106


Title :   Identification of G-Protein-Coupled Receptors (GPCRs) in Pulmonary Artery Smooth Muscle Cells as Novel Therapeutic Targets


Descriptive Note : Technical Report,02 Sep 2016,01 Sep 2017


Corporate Author : University of California San Diego La Jolla United States


Personal Author(s) : Insel, Paul


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1045106.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 12


Abstract : Pulmonary arterial hypertension (PAH) is associated with increased vascular resistance, sustained contraction, and enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs). The underlying idea of this project is that the currently limited treatments for PAH represent an unmet medical need for soldiers, veterans and those in the general population. We are testing the hypothesis that the discovery of novel (i.e., not previously recognized) G-protein-coupled receptors (GPCRs)and their functional activity in the PASMCs from subjects with PAH can reveal new insights into pathophysiology and new therapeutic targets for PAH. Our approach is to isolate PASMCs from PAH subjects and controls, to define the expression and function of their complement of GPCRs, with the goal of identifying GPCRs that have known physiologic agonists and are uniquely expressed and/or prominently up-regulated in PAH-PASMCs and to define their potential as novel therapeutic targets for PAH.


Descriptors :   PULMONARY HYPERTENSION , RECEPTOR SITES (PHYSIOLOGY) , proteins , MUSCLE CELLS , smooth muscle , pathophysiology , Hypoxia , drugs , rna sequence analysis , ribonucleic acids , gene expression


Subject Categories : Medicine and Medical Research
      Biochemistry
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE