Accession Number : AD1045046


Title :   Evaluation of Novel Antimicrobial Peptides as Topical Anti-Infectives with Broad Spectrum Activity Against Combat-Related Bacterial and Fungal Wound Infections


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Riptide Bioscience, Inc. Vallejo United States


Personal Author(s) : Clemens, Louis E


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1045046.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 10


Abstract : Ballistic wound infection has become the greatest threat to the life and recovery of the combat casualty who survives the immediate trauma of the insult. Multidrug resistance and generation of recalcitrant biofilm are major obstacles in treating wounds. Antimicrobial peptides (AMPs), also known as host defense peptides, are evolutionarily highly conserved components of the innate immune system that provide the first line of defense against invading pathogens in all multicellular organisms. Designed antimicrobial peptides (dAMPs) are synthesized peptides that have been rationally designed based on sequences found in naturally occurring AMPs. dAMPs are amphipathic cationic peptides with the ability to kill microbes by disrupting their membrane function. This mode of action rapidly kills antibiotic resistant microbes, even in biofilm. Bacteria have never succeeded in developing resistance to a variety of AMPs.


Descriptors :   WOUND INFECTIONS , ballistics , military personnel , combat operations , trauma , CASUALTIES , peptides , immune system


Subject Categories : Weapons Effects(biological)


Distribution Statement : APPROVED FOR PUBLIC RELEASE