Accession Number : AD1038409


Title :   Reconstructing Cell Lineages from Single-Cell Gene Expression Data: A Pilot Study


Descriptive Note : Technical Report,01 Jul 2014,31 Mar 2015


Corporate Author : Dana-Farber Cancer Institute, Inc. Boston United States


Personal Author(s) : Yuan,Guo-Cheng


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1038409.pdf


Report Date : 30 Aug 2016


Pagination or Media Count : 8


Abstract : The goal of this pilot study is to develop novel mathematical methods, by leveraging tools developed in the bifurcation theory, to infer the underlying cell-state dynamics from single-cell gene expression data. Our proposed method contains two steps. The first step is to reconstruct the temporal order of the cells from gene expression data, whereas the second step is to model the dynamic changes of gene expression patterns. The tools developed here will be useful for reconstruct developmental trajectories from single-cell gene expression data.


Descriptors :   GENE EXPRESSION , GENOMICS , Computational Biology , BIRUFICATION (MATHEMATICS) , erythroid cells , chromosome structures , transcription factors , cell line


Subject Categories : Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE