Accession Number : AD1034022


Title :   Regulatory T Cell-Enriching Microparticles for Promoting Vascularized Composite Allotransplant Survival


Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016


Corporate Author : University of Pittsburgh Pittsburgh United States


Personal Author(s) : Little,Stephen R ; Gorantla,Vijay ; Fisher,James


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1034022.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 11


Abstract : The purpose of this work is to investigate the ability of engineered biomimetic drug delivery systems to prevent rejection and promote immunological tolerance in the context of composite tissue allotransplantation (CTA). For this reporting period our goals were to fabricate and characterize microparticles to be used in animal surgeries, achieve IACUC/ACURO approval for animal work and start the first phase of rodent hindlimb transplants. Particles containing IL-2,TGFb, and rapamycin were fabricated and this triple cocktail, along with all pairwise iterations of the three components were tested for their ability to prevent hindlimb rejection (via 2 subcutaneous injections). Data at present seems to suggest that the combination of all three factors yields the best results, however some groups are still in the follow up period and accordingly, no statistical significance can be claimed until the follow up period is completed (this will happen within the next month).


Descriptors :   transplants , BIOMIMETICS , drug therapy , composite materials , biomedical research , rejection , particles , mice , EXTREMITIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE