Accession Number : AD1033191


Title :   Bioengineered Hydrogel to Inhibit Post-Traumatic Central Nervous System Scarring


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : University of Washington Seattle United States


Personal Author(s) : Horner,Philip J ; Pun,Suzie H


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1033191.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 22


Abstract : We have successfully synthesized and characterized an injectable hydrogel biomaterial with tunable thermosensitivity and the capability for covalent attachment of therapeutic peptides. This new material can be tuned and tested with the purpose of delivery a gel to the injured brain that becomes responsive to the injury environment. This work resulted in a publication in the Journal of Controlled Release (J Control Release. 2015 Jun 28;208:76-84).


Descriptors :   trauma , hydrogels , stem cells , REGENERATION (PHYSIOLOGY) , BIOENGINEERING , central nervous system , SCARS , inhibition , BLOOD COAGULATION , spinal cord , wounds and injuries , drugs , mechanical properties , temperature , polymers , BIOCOMPATIBLE MATERIALS , peptides


Subject Categories : Biomedical Instrumentation and Bioengineering
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE