Accession Number : AD1033070


Title :   Environmental Mycobiome Modifiers of Inflammation and Fibrosis in Systemic Sclerosis


Descriptive Note : Technical Report,20 Aug 2015,19 Aug 2016


Corporate Author : University of California San Francisco United States


Personal Author(s) : Arron,Sarah ; Whitfield,Michael ; Lafyatis,Robert


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1033070.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 20


Abstract : This project is focused on Systemic Sclerosis (SSc), a progressive fibrotic disease characterized by skin fibrosis and damage to internal organs. While a wide range of environmental and biological triggers have been proposed, no definitive etiologic agents have yet been identified. Metagenomic analysis of non-human sequences in SSc RNA-seq data was used to detect microbial sequences in human tissues in an unbiased, quantitative manner. Our studies suggest that disease pathogenesis includes a common environmental fungal trigger, Rhodotorula glutinis, which we hypothesize elicits immune activation in a permissive host genetic background.Skin biopsies have been collected from SSc patients and analyzed by high-throughput sequencing, providing substantial gene expression data as well as detailed information regarding the host microbiome. Data have been compared against that of healthy control samples.


Descriptors :   clinical trials , genomics , macrophages , mononuclear phagocyte system , myeloid cells , immune system , therapeutics , genetics , proteins , gene expression , fungi , fibrosis , sclerosis , ORGANS (ANATOMY) , PATHOLOGIC PROCESSES , skin , inflammation


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE