Accession Number : AD1013035


Title :   Mechanisms of Ionizing Radiation-Induced Cell Death in Primary Lung Cells


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States


Personal Author(s) : Panganiban,Ronald A


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1013035


Report Date : 05 Mar 2013


Pagination or Media Count : 104


Abstract : Exposure to high doses of ionizing radiation (IR) causes serious biological damage that can lead to death. During the course of radiotherapy, the use of IR for the treatment of thoracic cancers is limited by IR-induced cell death to the underlying normal lung tissue potentially leading to pneumonitis and/or fibrotic remodeling of the lung. Studies on the mechanisms of IR-induced cell death have been exponentially increasing, however, most of these studies are conducted on immortalized cancer cell lines that are not lung-derived and therefore do not represent the biological status of normal lung cells. We investigated the mechanisms of IR-induced cell death in low passage cultures of primary pulmonary artery endothelial cells (PAEC) exposed to varying doses of X-rays. We observed that irradiated PAEC undergo accelerated senescence as the primary mode of cell death at doses examined.


Descriptors :   lung diseases , Lung cancer , ionizing radiation , Radiotherapy , cell line


Distribution Statement : APPROVED FOR PUBLIC RELEASE