Accession Number : AD1011465


Title :   Mechanisms of Synaptic Alterations in a Neuroinflammation Model of Autism


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : University of Nebraska Medical Center Omaha United States


Personal Author(s) : Dunaevsky,Anna ; Li,Ming


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1011465


Report Date : 01 Oct 2015


Pagination or Media Count : 18


Abstract : Here we investigated how Maternal Immune Activation (MIA), a risk factor for autism spectrum disorders (ASD) affects the development of synapses. The central hypothesis is that altered expression of cytokines and chemokines in the brain results in impaired synaptic development and altered behavior. We employed the MIA mouse model and so far found that in offspring there is a reduction in the number of synaptic structures in vivo as well as reduced motility. Behavioral impairments relevant to ASD are also reported.


Descriptors :   synapse , inflammation , Cytokines , behavior , mice , drugs


Distribution Statement : APPROVED FOR PUBLIC RELEASE