Accession Number : AD1011389


Title :   New Epigenetic Therapeutic Intervention for Metastatic Breast Cancer


Descriptive Note : Technical Report,15 Mar 2015,14 Mar 2016


Corporate Author : University of Kentucky Lexington United States


Personal Author(s) : Zhou,Binhua P


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1011389


Report Date : 01 Apr 2016


Pagination or Media Count : 13


Abstract : Triple-negative breast cancer (TNBC) distinguishes from other forms of breast cancer in origination and progression. Likely originated from undifferentiated cancer stem cells, TNBC tumor cells possess many epithelial-mesenchymal transition (EMT) characteristics including invasion, resistance to apoptosis, and cancer stem cell-like traits that permit tumor dissemination and growth at distant sites. The Wnt pathways are important for EMT. We recently discovered that Wnt5a and its transcription factor Twist are markedly over-expressed in TNBC but not luminal breast cancer cells. We also discovered that constitutively activated NF-kB in TNBC sustains prolonged activation of pro-inflammatory cytokines, enabling rapid spread (metastasis) of TNBC tumors. Notably, the functions of both transcription factors Twist and NF-kB in gene activation require lysine acetylation, which signs to activate the transcriptional machinery in chromatin.


Descriptors :   BREAST CANCER , METASTASIS , INTERVENTION , THERAPY


Distribution Statement : APPROVED FOR PUBLIC RELEASE