Accession Number : AD1011376


Title :   Linking Cholesterol to Cancer: Circulating 27-Hydroxycholesterol and Breast Cancer Risk by Tumor Subtype and Expression of CYP27A1 and CYP7B1


Descriptive Note : Technical Report,01 Mar 2015,29 Feb 2016


Corporate Author : Deutsches Krebsforschungszentrum Heidelberg Germany


Personal Author(s) : Fortner,S R


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1011376


Report Date : 01 Apr 2016


Pagination or Media Count : 10


Abstract : Following intriguing data from experimental models, this study investigates cholesterol metabolite 27-hydroxycholesterol and breast cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort. This study capitalizes on the availability of pre-diagnostic serum samples, as well as tumor tissue samples on a subset of the cases. Grant year 1 was dedicated to study start-up, and included finalization of ethical approvals, selection and characterization of eligible breast cancer cases and matched controls from the EPIC-Heidelberg cohort, and identification and characterization of eligible cases for tissue microarray (TMA) analyses. A total of 530 cases and 1036 controls were selected into the overall investigation. A total of 360 of the cases are included on TMAs for immunohistochemistry analyses. Cases and controls were median age 53at blood collection, and cases were median age 61 at diagnosis. Serum and TMA laboratory work will be completed in grant year 2.


Descriptors :   breast cancer , cholesterol , risk , neoplasms , tissues(biology) , enzymes , metabolism


Distribution Statement : APPROVED FOR PUBLIC RELEASE