Accession Number : AD1011221


Title :   Injury, inflammation and the emergence of human specific genes


Descriptive Note : Journal Article


Corporate Author : University of California San Diego School of Medicine, La Jolla San Diego United States


Personal Author(s) : Baird,Andrew ; Constantini,Todd ; Coimbra,Raul ; Eliceiri,Brian P


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1011221.pdf


Report Date : 12 Jul 2016


Pagination or Media Count : 5


Abstract : In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.


Descriptors :   inflammation , gene expression , wounds and injuries , models , infection , leukocytes , human behavior , human genome


Distribution Statement : APPROVED FOR PUBLIC RELEASE