Accession Number : AD1009098


Title :   Complement Activation Alters Platelet Function


Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2015


Corporate Author : Beth Israel Deaconess Medical Center Boston United States


Personal Author(s) : Tsokos,George


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1009098


Report Date : 01 Dec 2015


Pagination or Media Count : 9


Abstract : We have established base line criteria that will allow us to evaluate the role of platelets during trauma. These studies have started to unravel the relationship between platelets and complement and their contribution to tissue damage. It seems that complement C3 does not deposit on the surface of platelets following ischemia/reperfusion. Yet, we have seen the deposition of both C3 and platelets in various tissues following IRI in a similar time frame. Further studies will evaluate if these factors co-localize in tissue. We have developed B6.lprPF4-/- mice which will allow us to better study the role of PF4 in tissue damage. Preliminary studies indicate a decreased level of platelets in these mice, suggesting a decreased level of disease. Further studies will expand upon these observations better outlining the function of platelets in the injury associated with trauma. Ultimately these studies will allow us to develop specific treatment strategies that limit battlefield tissue injury without affecting haemostatic and coagulation properties of platelets.


Descriptors :   blood platelets , complement(biology) , trauma , tissues(biology) , wounds and injuries , ischemia , coagulation , COMBAT CASUALTY CARE , therapeutics


Distribution Statement : APPROVED FOR PUBLIC RELEASE