Accession Number : AD1003343

Title :   Development of an Animal Model of Thoracolumbar Burst Fracture Induced Acute Spinal Cord Injury

Descriptive Note : Technical Report,01 May 2014,30 Apr 2015

Corporate Author : John Hopkins University Baltimore United States

Personal Author(s) : Sciubba,Daniel M ; Petteys,Rory J ; Freedman,Brett A

Full Text :

Report Date : 01 May 2015

Pagination or Media Count : 7

Abstract : Here, we describe the design and development of a controlled spinal cord impactor for use in large animal models of SCI in order to more reliably recreate the human injury. A custom designed spinal cord impactor and mounting platform were fabricated to be placed anteriorly or posteriorly over a large animal (e.g., pig, sheep, dog). Repeated impacts demonstrated predictable results with less than 10% variability at each target force. The average impact duration was 71.2 +/- 6.1 msec. At a 40 Newton target, the output force was 41.5 N +/- 1.7%. With a 25 N target, the output was 23.5 N +/- 2.7%; a 15 N target revealed an output of 15.2 N +/- 9.3%. This novel custom designed spinal cord impactor is capable of reliably delivering precise impacts to the spinal cord and will be utilized in future research to study acute traumatic spinal cord injury in a large animal.

Descriptors :   models , spinal cord , trauma , medical research , animals , impact

Distribution Statement : APPROVED FOR PUBLIC RELEASE