Accession Number : AD1003314


Title :   Autism and Obesity: Co-Occurring Conditions or Drug Side Effects


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Children's Mercy Hospital Kansas City United States


Personal Author(s) : Talebizadeh,Zohreh


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1003314.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 11


Abstract : [1] IRB protocol has been submitted and an Exempt status has been determined for the project. [2] Weight/Height data has been obtained from the AGRE database and BMI has been calculated for autistic subjects (n=552). Autistic subjects were then classified based on the BMI data into obese, overweight, healthy and underweight categories. [3] Using a rigorous literature search dbSNP search, we collected data on 157 AIWG SNPs and used multiple tools and selection criteria to identify Tag SNPs for these SNPs. [4] We found SNAP (SNP Annotation and Proxy Search) tool to be the most useful for selecting Tag SNPs. [5] We downloaded AGRE genotyping data (combined Affymetrix and Illumina platforms). We are examining this genotyping list for the presence of the AIWG Master List SNPs and the identified Tag SNPs. [6] We began developing a statistical pipeline for analyzing the genotyping data (bioequivalence tests). A poster was presented at the annual ASHG meeting summarizing the current status of our statistical method.


Descriptors :   CLINICAL TRIALS


Distribution Statement : APPROVED FOR PUBLIC RELEASE