Accession Number : AD1003301


Title :   Identifying microRNAs that Regulate Neuroblastoma Cell Differentiation


Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015


Corporate Author : University of Texas Health Science Center San Antonio United States


Personal Author(s) : Du,Liqin ; Zhao,Zhenze ; Pertsemlidis,Alexander ; Ma,Xiuye


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1003301


Report Date : 01 Oct 2015


Pagination or Media Count : 27


Abstract : In this reporting period, we mainly focused on characterizing another novel differentiation-inducing miRNA, miR-449a. We examined the differentiation-inducing function of miR-449a in multiple neuroblastoma cell lines. We have demonstrated that miR-449a functions as an inducer of cell differentiation in neuroblastoma cell lines with distinct genetic backgrounds, including the MYCN amplification status. We further show that miR-449s mimic induces cell cycle exit, induces cell apoptosis, and decreases the capacity of the neuroblastoma cells to form colonies. Our results support the strong tumor suppressive function of miR-449a in neuroblastoma cells, providing the experimental evidence for developing miR-499a-based differentiation therapy for neuroblastoma.


Descriptors :   NEUROBLASTOMA


Distribution Statement : APPROVED FOR PUBLIC RELEASE