Accession Number : AD1002998


Title :   Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions


Descriptive Note : Technical Report,15 Jul 2012,14 Jul 2015


Corporate Author : University of Michigan Ann Arbor United States


Personal Author(s) : El-Sayed,Mohamed E


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1002998


Report Date : 01 Oct 2015


Pagination or Media Count : 34


Abstract : In this project, we developed the amphiphilic PEG-b-(PAA)-b-P(HDFMA-co-MMA) copolymers that can encapsulate PFP or PFH forming nanodroplets (200 nm). Combining these nanodroplets with histotripsy proved to generate a cavitation bubble cloud with similar behavior but lower pressure compared to histotrIpsy itself. We investigated physical mechanisms underlying the nanodroplet cavitation process with playing different transducer frequencies (0.345, 0.5, 1, 3 MHz), changing the core PFC (PFP: boiling point 29 C or PFH: boiling point 56 C)and as well as cavitation nucleation is caused by the negative pressure (p-) exposed to the PFC. Under the light of these findings we established nanodroplet mediated histotripsy cell cavitation on 3D prostate cancer spheroid models.


Descriptors :   PROSTATE CANCER , DIAGNOSTIC EQUIPMENT


Distribution Statement : APPROVED FOR PUBLIC RELEASE