Accession Number : AD1002994


Title :   Screening for Novel Germline Rare Mutations Associated with Aggressive Prostate Cancer


Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2015


Corporate Author : Wake Forest University Winston Salem United States


Personal Author(s) : Chen,Zhuo


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1002994


Report Date : 01 Dec 2015


Pagination or Media Count : 24


Abstract : Prostate cancer is the most common noncutaneous cancer in males in the U.S. While the major indolent form maynot even require treatment, about 10-15% of PCa cases of aggressive form requiring intensive treatment. However, our inability to reliably distinguish between aggressive and indolent PCa early on in the course of the disease has resulted in the over-treatment of many and under treatment of some. We hypothesize that inherited sequence variants in the genome are associated with PCa aggressiveness. Currently, we conducted single variant analysis and gene-based analysis to identify rare variants that have strong effects on aggressive PCa risk in exome-array data among a total of 1,902 PCa cases of European descent, including 464 aggressive PCa cases and 1,438 indolent PCa cases. We successfully identified 11 novel variants associated with PCa aggressiveness in Caucasians and further confirmation in additional Caucasians and African American men are to be conducted. Our study will provide more insight into the etiology of aggressive PCa and provide potential effective targets for therapy of aggressive PCa.


Descriptors :   prostate cancer


Distribution Statement : APPROVED FOR PUBLIC RELEASE