Accession Number : AD1002636


Title :   Mitochondrial Based Treatments that Prevent Post Traumatic Osteoarthritis in a Translational Large Animal Intraarticular Fracture Survival Model


Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015


Corporate Author : University of Iowa Iowa City United States


Personal Author(s) : Martin,James A


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1002636.pdf


Report Date : 01 Sep 2015


Pagination or Media Count : 11


Abstract : The purpose of this research is to investigate a novel therapeutic approach to prevent PTOA by treating mitochondrial dysfunction in chondrocytes resulting from an intraarticular injury. To date, we have shown that all of the drugs targeting mitochondrial mechanotransduction and oxidant production that we have tested are chondroprotective to some degree. We are currently awaiting pig model sacrifices upon completion of the 6- and 12- month time points.


Descriptors :   therapeutics , Arthritis , JOINT DISEASES , stress , mitochondria , wounds and injuries , drug therapy , ANIMAL EXPERIMENTATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE