Accession Number : AD1002201


Title :   Targeting the Adipocyte Tumor Cell Interaction in Prostate Cancer Treatment


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Sanford-Burnham Medical Research Institute La Jolla United States


Personal Author(s) : Moscat,Jorge


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/1002201.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 45


Abstract : Prostate cancer (PCa) is one of the leading causes of death among men in the United States. Obesity is another growing epidemic health problem in Western societies and in developing nations, and represents one of the greatest threats to global human health. Several epidemiological studies during the last decade have pointed to an association between obesity and increased risk factor for PCa progression and aggressiveness. However, despite the relatively high amount of epidemiological data available, little is known about the molecular basis underlying the association between PCa progression, obesity and inflammation, and the role of the adipocyte-cancer cell interaction in this process. The goal of this project is to test the hypothesis that p62 is a molecular link in the cross-talk between obesity, inflammation and prostate cancer progression. Here, we have generated a new mouse model to address this question. Unveiling the molecular mechanisms governing obesity induced prostate cancer progression will have a great impact in our understanding of this process, and its relevance for potential more targeted and efficacious therapies in PCa.


Descriptors :   prostate cancer , OBESITY , inflammation , metastasis , adipocytes


Distribution Statement : APPROVED FOR PUBLIC RELEASE