Accession Number : AD1001742


Title :   Preclinical Testing of a New MR Imaging Approach to Distinguish Aggressive from Indolent Disease


Descriptive Note : Technical Report


Corporate Author : The Regents of University of California San Francisco United States


Personal Author(s) : Vigneron,Daniel B


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD1001742


Report Date : 01 Aug 2015


Pagination or Media Count : 12


Abstract : The aim of this project was to develop a new MRI approach to characterize aggressive prostate cancers and differentiate them from low grade tumors based on genetic/proteomic induced metabolic differences and perfusion abnormalities. The project was designed to then apply this new approach in preclinical transgenic prostate cancer models to obtain the required preliminary data for future clinical trials. This project has gone extremely well accomplishing the technical milestones described in the original approved Statement of Work (SOW) and performing the unprecedented prostate cancer model studies demonstrating the ability of these new methods to measure significantly different metabolic and perfusion parameters inaggressive high grade cancers compared to low grade. The results of this project demonstrate feasibility and strongly support the hypothesis that this new approach can distinguish aggressive from indolent prostate cancer. This project has resulted in new technical advances and the strong preclinical data that will serve as the basis for justifying and designing future clinical trials investigating their value in patients with prostate cancer.


Descriptors :   prostate cancer , models


Distribution Statement : APPROVED FOR PUBLIC RELEASE