Accession Number : AD0787464


Title :   Polydimethylsiloxane: A Feasibility Study of a Thromboresistant Biomaterial,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Weathersby,P. K. ; Kolobow,T. ; Stool,E. W.


Report Date : JUN 1974


Pagination or Media Count : 19


Abstract : Silicone rubber as used in blood contacting situations usually contains fillers, catalyst and other additives. In this study, polydimethylsiloxane (PDMS) alone was cross-linked by ionizing radiation in a nitrogen atmosphere to produce a 'pure' silicone rubber. This material exhibited a Lee-White clotting time over 45 minutes and a clotting time of 90 minutes when air-blood contact was minimized. Comparable times for commercial silicones are 25 and 60 minutes. In extracorporeal testing using a 'Mini Lung', an irradiated PDMS coated membrane demonstrated greatly improved thromboresistance over standard silicone rubber membranes. (Author)


Descriptors :   *BIOMOLECULES, *FIRE RESISTANT MATERIALS, BLOOD COAGULATION, MECHANICAL ORGANS, SYNTHETIC RUBBER.


Subject Categories : MEDICAL FACILITIES, EQUIPMENT AND SUPPLIES


Distribution Statement : APPROVED FOR PUBLIC RELEASE