Accession Number : AD0783022


Title :   The Failure of Buffered 5-Hydroxytryptamine to Increase Brain Capillary Permeability to Albumin.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Solomon,L. S.


Report Date : MAR 1974


Pagination or Media Count : 22


Abstract : The effect of buffered 5-hydroxytryptamine (5-HT) on the blood-brain barrier to 125I-albumin was studied in 14 rhesus monkeys. 5-HT was introduced into the lateral ventricle by ventriculocisternal perfusion resulting in a concentration gradient in the periventricular tissue from 1 to 800 times endogenous levels. Buffered 5-HT failed to induce an increase in periventricular vascular permeability to 125I-albumin. Earlier reports to the contrary may have resulted from species differences, as well as failure to control physiologic parameters and the use of highly acidic 5-HT preparations. (Author)


Descriptors :   *Brain, *Tryptophan, *Albumins, Indoles, Labeled substances, Monkeys, Capillaries(Anatomy)


Subject Categories : BIOCHEMISRTY


Distribution Statement : APPROVED FOR PUBLIC RELEASE