Accession Number : AD0783022
Title : The Failure of Buffered 5-Hydroxytryptamine to Increase Brain Capillary Permeability to Albumin
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Solomon, L S
Report Date : Mar 1974
Pagination or Media Count : 23
Abstract : The effect of buffered 5-hydroxytryptamine (5-HT) on the blood-brain barrier to 125I-albumin was studied in 14 rhesus monkeys. 5-HT was introduced into the lateral ventricle by ventriculocisternal perfusion resulting in a concentration gradient in the periventricular tissue from 1 to 800 times endogenous levels. Buffered 5-HT failed to induce an increase in periventricular vascular permeability to 125I-albumin. Earlier reports to the contrary may have resulted from species differences, as well as failure to control physiologic parameters and the use of highly acidic 5-HT preparations.
Descriptors : *ALBUMINS , *BRAIN , *TRYPTOPHAN , CAPILLARIES(ANATOMY) , INDOLES , LABELED SUBSTANCES , MONKEYS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE