Accession Number : AD0782675


Title :   Technetium-99m Pyrophosphate for Bone Imaging.


Descriptive Note : Technical note,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Eckelman,W. C. ; Reba,R. C. ; Kubota,H. ; Stevenson,J. S.


Report Date : APR 1974


Pagination or Media Count : 19


Abstract : Of the various 99mTc phosphates suggested for bone imaging, 99mTc pyrophosphate appears to have the desirable characteristics of commercial availability of sodium pyrophosphate and availability of analytical controls to assure the quality of the final product. Systematic variations of the parameters of the 99mTc tin pyrophosphate preparation were evaluated by gamma camera images in swine. These studies indicate that the best tissue distribution is obtained by adding 1.75 ml of 0.1 M sodium pyrophosphate at pH 10 to 0.25 ml of 1 mg/ml tin chloride followed by 1.50 ml 99mTcO4(-). In vivo organ distribution indicates the importance of normalizing doses on a per weight basis for comparative animal studies. If the proper dose of phosphate is used, 99mTc pyrophospate results in high quality bone images in animals and humans and can be easily prepared and assayed. (Modified author abstract)


Descriptors :   *Technetium compounds, *Radiology, *Phosphates, Images, Bones, Tissues(Biology), Organs(Anatomy), Dosage, Body weight


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE