Accession Number : AD0777032


Title :   Bone Marrow Response of Beagles to Fractionated Doses of Mixed Gamma-Neutron Radiation


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : West, J E ; Mitchell, F A ; Jones, S R ; Witz, J


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0777032


Report Date : Sep 1973


Pagination or Media Count : 24


Abstract : Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 rads/minute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of this study was to determine if doses in the median lethal range delivered in four equal fractions at 24-hour intervals were more lethal and more damaging to survival-limiting hematopoietic cell renewal systems than similar unfractionated doses. Single irradiations were the more lethal, first evident at 225 rads and increasing markedly in effectiveness at 240 rads. Radiation- induced changes in bone marrow cellularity were similar after single and fractionated irradiations. (Modified author abstract)


Descriptors :   *BONE MARROW, *RADIATION EFFECTS, DOGS, DOSE RATE, EXPERIMENTAL DATA, GAMMA RAYS, LABORATORY ANIMALS, LETHALITY, RADIATION DOSAGE, SUBLETHAL DOSAGE


Subject Categories : Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE