Accession Number : AD0770106
Title : Altered Gamma-Aminobutyric Acid Metabolism Early in the Postirradiation Response of the Rat
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Chaput, R. L. ; Zeman, G. H.
Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0770106
Report Date : SEP 1973
Pagination or Media Count : 16
Abstract : The metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) was studied in rats subjected to 10,000 or 20,000 rads of pulsed mixed gamma-neutron radiation. Whole brain GABA levels were found to rise above control levels by 20 minutes following 10,000 rads and as early as one minute following 20,000 rads. L-glutamic acid decarboxylase activity was also observed to rise as early as one minute following either dose of radiation. The results are consistent with the hypothesis that GABA is involved in the etiology of the transient central nervous system disorders (apathy, disorientation, ataxia) observed in rats shortly after high doses of ionizing radiation.
Descriptors : *RADIATION EFFECTS, *ORGANIC ACIDS, NERVOUS SYSTEM DISEASES, NEUROCHEMISTRY, RATS, BRAIN, METABOLISM
Subject Categories : BIOCHEMISRTY
Distribution Statement : APPROVED FOR PUBLIC RELEASE