Accession Number : AD0769172
Title : Kongenitale Chagas. Einfluss einer Trypanosoma Cruzi-Infektion auf die Embryonalentwicklung bei Traechtigen Maeusen (Congenital Chagas Diseases. Effect of 'Trypanosoma cruzi' Infection on Embryogeny in Gravid Mice),
Corporate Author : ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)
Personal Author(s) : Werner,H. ; Egger,I.
Report Date : APR 1971
Pagination or Media Count : 12
Abstract : Congenital Chagas' disease in man and animals entailing abortion, premature delivery and deformation has been reported in the literature, although Trypanosoma cruzi is evidently not capable of penetrating the intact placental barrier between the maternal and fetal circulation. In the present study, the effect of T. cruzi infection on the fetal development of mice has been investigated after inoculating three different strains of T. cruzi in their mothers during the first, second and third week of gestation. Compared with non-gravid mice infected with T. cruzi, which showed scattered pseudocysts in the endometrium and the muscularis uteri but no marked tropism of the trypanosomes, more pseudocysts containing amatigote forms at various stages of development were found in those tissues of gravid animals than in any other organ. The high parasite density in the surrounding tissues resulted in either early death or retarded growth of the embryos and fetuses, although trypanosomes were not demonstrable in injured fetuses (however, parasites were demonstrated in normally developed fetuses from seven mothers by means of isodiagnosis). The injurious effect, the extent of which is dependent on the time of infection and virulence of the particular strain, is attributed to such factors as defective nutrition of the embryos, metabolic products of the trypanosomes, and toxic products of the disintegrated host cells.
Descriptors : *CHAGAS DISEASE, *GENETICS, *EMBRYOLOGY, TRYPANOSOMA, TRYPANOSOMIASIS, INFECTIOUS DISEASES, PLACENTA, ABNORMALITIES, PREGNANCY, LABORATORY ANIMALS, MICE, WEST GERMANY, PROTOZOA.
Subject Categories : MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE