Accession Number : AD0764885


Title :   Increased Brain Radioresistance After Supralethal Irradiation,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Chaput,R. L. ; Berardo,P. A. ; Barron,E. L.


Report Date : MAY 1973


Pagination or Media Count : 28


Abstract : Clinical symptoms and performance were evaluated after shuttlebox-trained miniature pigs received two 4400-rad doses separated by time intervals of .0001 to 30 minutes. The doses were delivered to the head by 45 MeV electrons from the AFRRI electron linear accelerator (LINAC). There was no significant difference in neurological symptoms (convulsions, coma, ataxia) or in performance after the second dose between animals that received the two doses .0001 or 0.3 minute apart. As the time interval between doses was increased from 0.3 to 3 minutes, however, neurological symptoms declined and performance improved markedly after the second dose. When the doses were 30 minutes apart, the pigs showed no decrease in performance within the initial 30 minutes postirradiation. It was concluded that more than physicochemical processes were involved in the increased radioresistance to the second dose of radiation. (Author)


Descriptors :   (*RADIATION TOLERANCE, BRAIN), LETHAL DOSAGE, DOSE RATE, PERFORMANCE(HUMAN), CENTRAL NERVOUS SYSTEM, SWINE, EXPERIMENTAL DATA


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE