Accession Number : AD0757661


Title :   The Relationship of Blood-Brain Barrier Damage to Survival Time after Acute Radiation Injury.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Wyant,D. E. ; Kabal,J. ; Baum,S. J. ; Parkhurst,L. J.


Report Date : NOV 1972


Pagination or Media Count : 13


Abstract : The purpose of this study was to investigate whether a relationship exists between alterations of the blood-brain barrier (BBB) and the survival time of rats exposed to supralethal irradiation. BBB alterations were produced by injection of glycerol, mercuric chloride, or by lymphatic cervical blockade. Animals were subsequently exposed to a supralethal dose of radiation, and the survival times of various groups were compared. The production of BBB alterations prior to irradiation did not influence the survival time of rats after exposure to supralethal doses of radiation suggesting that BBB damage may bear no direct relationship to the survival time after radiation injury. (Author)


Descriptors :   *CEREBROVASCULAR SYSTEM, *RADIATION INJURIES, BLOOD CIRCULATION, RADIATION DOSAGE, CAPILLARIES(ANATOMY), BRAIN, SURVIVAL(PERSONNEL), RATS, EXPERIMENTAL DATA.


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE