Accession Number : AD0732391
Title : The Measurement of Capillary Permeability Changes in the Irradiated Rat Using a Double Isotope Technique
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Graham, M M
Report Date : Sep 1971
Pagination or Media Count : 25
Abstract : Capillary permeability was measured using 131I albumin and 125I albumin to assay the movement of albumin out of the bloodstream into the interstitial fluid of small intestine and muscle of the irradiated rat. One hour after 800 rads 30 MeV electron whole-body irradiation, small intestine capillary permeability increased significantly, returned to normal levels in a few hours, and then after 8 hours increased and remained at 65 percent above control levels for several days. Muscle capillary permeability increased within 2 hours after irradiation and remained elevated for several days. Cyproheptadine, an antiserotonin-antihistamine, completely blocked a 45 percent increase in small intestine capillary permeability seen immediately after 10,000 rads 60Co irradiation but had little effect at 48 hours after irradiation.
Descriptors : *CAPILLARIES(ANATOMY) , *RADIATION EFFECTS , BLOOD CIRCULATION , BLOOD VESSELS , INTESTINES , MUSCLES , PERMEABILITY
Subject Categories : Radiobiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE