Accession Number : AD0727982


Title :   Radiation Inactivation of Histamine in Aqueous Solution and in Plasma.


Descriptive Note : Technical note,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Doyle,T. F. ; Bradley,S. L.


Report Date : JUL 1971


Pagination or Media Count : 15


Abstract : Dilute solutions of histamine in water and plasma were given 140- to 38,000-rad doses of pulsed mixed gamma-neutron radiation. Histamine activity of the solutions was bioassayed using guinea pig ileum. Inactivation of the histamine in water was apparent at doses of 2000 rads or more. Different concentrations of histamine receiving the same dose of radiation showed an inverse relation between concentration and inactivation. Histamine in plasma showed less than 10 percent inactivation even at the highest dose used, 38,000 rads. (Author)


Descriptors :   (*HISTAMINE, *RADIATION EFFECTS), GAMMA RAYS, NEUTRONS, BLOOD PLASMA, BLOOD ANALYSIS, MONKEYS


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE