Accession Number : AD0724294


Title :   Humoral Antibody Responses in Newborn Monkeys after Mixed Gamma-Neutron Irradiation.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Bowser,B. T. ; Exum,E. D.


Report Date : FEB 1971


Pagination or Media Count : 17


Abstract : Newborn monkeys exposed to 200 rads of mixed gamma-neutron radiation and subsequently injected with bovine serum albumin (BSA), incorporated in saline, produced antibody titers that were significantly higher than those observed in the corresponding nonirradiated controls (p<0.05). The titers of irradiated animals injected with BSA incorporated in adjuvant (incomplete Freund type) while higher than those of the nonirradiated controls were not significantly different. Irradiated monkeys receiving BSA in adjuvant and neoplastic tissue simultaneously exhibited significantly lower titers than those monkeys which were administered neoplastic tissues 4 or more days after BSA injections. The enhanced antibody responses seen in the newborn monkey are viewed as unusual responses while the depressed responses are recognized as more typical. Positive explanations for both responses are discussed. (Author)


Descriptors :   (*RADIOBIOLOGY, *IMMUNOLOGY), (*RADIATION EFFECTS, ANTIGEN ANTIBODY REACTIONS), IMMUNITY, GAMMA RAYS, NUCLEAR RADIATION, MONKEYS


Subject Categories : ANATOMY AND PHYSIOLOGY
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE