Accession Number : AD0713087
Title : A HISTOCHEMICAL STUDY OF LIVER ENZYMES INVOLVED IN GLYCOGEN METABOLISM IN THE X-IRRADIATED RAT
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Catravas, G N ; McHale, C G
Report Date : Jun 1970
Pagination or Media Count : 24
Abstract : The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x rays. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase, both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4 to 1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be enhanced.
Descriptors : *ENZYMES , *GLYCOGEN , *METABOLISM , *RATS , GLUCOSE , GLYCOSIDE HYDROLASES , IN VIVO ANALYSIS , LIVER , RADIATION EFFECTS , WHOLE BODY IRRADIATION , X RAYS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE