Accession Number : AD0713087


Title :   A HISTOCHEMICAL STUDY OF LIVER ENZYMES INVOLVED IN GLYCOGEN METABOLISM IN THE X-IRRADIATED RAT


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Catravas, G N ; McHale, C G


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0713087


Report Date : Jun 1970


Pagination or Media Count : 24


Abstract : The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x rays. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase, both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4 to 1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be enhanced.


Descriptors :   *ENZYMES, *GLYCOGEN, *METABOLISM, *RATS, GLUCOSE, GLYCOSIDE HYDROLASES, IN VIVO ANALYSIS, LIVER, RADIATION EFFECTS, WHOLE BODY IRRADIATION, X RAYS


Subject Categories : Biochemistry
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE