Accession Number : AD0713087


Title :   A HISTOCHEMICAL STUDY OF LIVER ENZYMES INVOLVED IN GLYCOGEN METABOLISM IN THE X-IRRADIATED RAT.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Catravas,G. N. ; McHale,C. G.


Report Date : JUN 1970


Pagination or Media Count : 24


Abstract : The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x rays. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase, both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4 to 1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be enhanced. (Author)


Descriptors :   (*GLYCOGEN, METABOLISM), (*RATS, WHOLE BODY IRRADIATION), (*METABOLISM, WHOLE BODY IRRADIATION), (*ENZYMES, LIVER), GLYCOSIDE HYDROLASES, RADIATION EFFECTS, X RAYS, IN VIVO ANALYSIS, GLUCOSE


Subject Categories : BIOCHEMISRTY
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE