Accession Number : AD0709938


Title :   MINIATURE PIG PERFORMANCE AFTER FRACTIONATED DOSES OF RADIATION: TIME-DOSE RELATIONSHIPS,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Chaput,R. L. ; Kovacic,R. T.


Report Date : JUN 1970


Pagination or Media Count : 24


Abstract : Miniature pigs were trained to traverse, on cue, a two-chambered shuttlebox. Six groups of five to eight pigs received a 4400-rad midline tissue dose of pulsed mixed gamma-neutron radiation followed 1/2, 1, 5, 15, 24, or 51 hours later by a second dose of equivalent magnitude. Two other groups of eight pigs received a lower initial dose (1700 or 3400 rads) followed 1 hour later by a second dose of 4800 to 5000 rads. In addition, unfractionated doses of either 4500 or 8600 rads were given to two groups of six pigs. Regardless of the time interval between the two 4400-rad doses, performance was generally better after the second dose than after the first. Early transient incapacitation, accompanied always by convulsions, and occasionally by coma, consistently occurred after the first dose but was infrequent after the second. When early transient incapacitation did occur after the second dose, it was generally shorter than after the first dose and accompanied by ataxia and disorientation; convulsions and coma were very infrequent. Because of this reduced response to the second 4400-rad dose, performance after an 8800-rad fractionated dose was markedly better than after an 8600-rad unfractionated dose. (Author)


Descriptors :   (*CONDITIONED RESPONSE, *RADIATION EFFECTS), SWINE, GAMMA RAYS, NUCLEAR RADIATION, RADIATION DOSAGE, PATHOLOGY, DOSE RATE, SPACE PERCEPTION, SURVIVAL(PERSONNEL), PHYSIOLOGY


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE