Accession Number : AD0705996


Title :   ACTIVITY OF RAT LIVER ENZYMES RESPONSIBLE FOR GLYCOGEN METABOLISM AFTER WHOLE-BODY IRRADIATION,


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Catravas,G. N. ; McHale,C. G.


Report Date : APR 1970


Pagination or Media Count : 26


Abstract : The activities of liver enzymes involved in the breakdown and synthesis of glycogen have been investigated in rats exposed to 1200 rads midline kerma dose, free-in-air, of x rays or mixed gamma-neutron radiation. It was found that glycogen phosphorylase and amylo-1,6-glucosidase, both of which are involved in the breakdown of glycogen to 3glucose3 units, are greatly inhibited by both qualities of radiation. A considerable inhibition in the activity of amylo-(1,4 to 1,6)-trans-glucosidase (branching enzyme) was also observed. In contrast, it was found that the activity of UDP-glucose-glycogen transglucosylase which is responsible for the in vivo synthesis of 1,4-polysaccharides is greatly enhanced when the animal received x rays or mixed gamma-neutron radiation. (Author)


Descriptors :   (*RADIATION EFFECTS, ENZYMES), (*ENZYMES, LIVER), (*GLYCOGEN, METABOLISM), WHOLE BODY IRRADIATION, X RAYS, NUCLEAR RADIATION, BIOSYNTHESIS, INHIBITION, RATS


Subject Categories : BIOCHEMISRTY
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE