Accession Number : AD0705996
Title : ACTIVITY OF RAT LIVER ENZYMES RESPONSIBLE FOR GLYCOGEN METABOLISM AFTER WHOLE-BODY IRRADIATION
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Catravas, G N ; McHale, C G
Report Date : Apr 1970
Pagination or Media Count : 27
Abstract : The activities of liver enzymes involved in the breakdown and synthesis of glycogen have been investigated in rats exposed to 1200 rads midline kerma dose, free-in-air, of x rays or mixed gamma-neutron radiation. It was found that glycogen phosphorylase and amylo-1,6-glucosidase, both of which are involved in the breakdown of glycogen to 3glucose3 units, are greatly inhibited by both qualities of radiation. A considerable inhibition in the activity of amylo-(1,4 to 1,6)-trans-glucosidase (branching enzyme) was also observed. In contrast, it was found that the activity of UDP-glucose-glycogen transglucosylase which is responsible for the in vivo synthesis of 1,4- polysaccharides is greatly enhanced when the animal received x rays or mixed gamma-neutron radiation.
Descriptors : *ENZYMES , *GLYCOGEN , *RADIATION EFFECTS , BIOSYNTHESIS , INHIBITION , LIVER , METABOLISM , NUCLEAR RADIATION , RATS , WHOLE BODY IRRADIATION , X RAYS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE