Accession Number : AD0695424


Title :   THE EFFECT OF X IRRADIATION ON DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Bowser, R. T. ; Spence, D. B. ; Exum, E. D.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0695424


Report Date : OCT 1969


Pagination or Media Count : 19


Abstract : Rats exposed to x radiation 24 hours prior to antigen administration exhibited detectable skin reactions to tuberculin 2 days later than nonirradiated sensitized controls. Reaction sizes illustrate that the irradiated rat experienced a decreased sensitivity to tuberculin which persisted through day 14. The radiation dose (475 rads) responsible for the observed depression of the delayed skin reactions produced a greater depression of the circulating antibody response. The results obtained suggest that the cellular and humoral immune responses in the rat are radiosensitive.


Descriptors :   *RATS, *RADIATION EFFECTS, RESPONSE(BIOLOGY), ALLERGIC DISEASES, SKIN(ANATOMY), RADIATION DOSAGE, ANTIGEN ANTIBODY REACTIONS, X RAYS, SENSITIVITY, IMMUNITY


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE