Accession Number : AD0689096


Title :   EFFECT OF X RAYS AND 60Co GAMMA RAYS ON THE LIVER ENZYME SYSTEM RESPONSIBLE FOR FATTY ACID SYNTHESIS


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Catravas, G. N.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0689096


Report Date : APR 1969


Pagination or Media Count : 22


Abstract : The report describes effects of in vivo exposure to x rays and 60Co gamma rays on the fatty acid synthesizing liver enzyme system. Both fed and fasted young female Sprague-Dawley rats were utilized in these studies. All irradiated animals received a single whole-body exposure of 1200 R at 20 R/min. The irradiated animals as well as sham irradiated controls were sacrificed at predetermined times after exposure and cell-free liver homogenates which contained the enzyme system under investigation were prepared. It was found that the activity of the liver enzyme system responsible for the biosynthesis of fatty acids is greatly stimulated by x or 60Co gamma rays and that the cytoplasmic soluble enzymes are affected by radiation to a much greater extent than the mitochondrial enzymes. Blood glucose determinations were carried out in irradiated and control rats as well as in rats which were made alloxan diabetic. The results indicate that the enhancement of enzyme activity observed is not due to an increase in the blood glucose level of the animal as a result of exposure to radiation but to some other factor the nature of which has not yet been elucidated.


Descriptors :   *ENZYMES, X RAYS, METABOLISM, GAMMA RAYS, LIVER, BLOOD CHEMISTRY, BIOSYNTHESIS, RADIATION DOSAGE, RADIATION EFFECTS, FATTY ACIDS, WHOLE BODY IRRADIATION, RATS, IN VIVO ANALYSIS


Subject Categories : BIOCHEMISRTY
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE