Accession Number : AD0674860


Title :   EFFECT OF PREIRRADIATION AND POSTIRRADIATION ERYTHROPOIETIC STIMULATION ON SURVIVAL FOLLOWING EXPOSURE TO HEMATOPOIETICALLY LETHAL X-RAY DOSES


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Okunewick, J. P. ; Hartley, K. M.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=AD0674860


Report Date : MAY 1968


Pagination or Media Count : 22


Abstract : Experiments were carried out to evaluate the effect of erythropoietic stimulation on postirradiation survival. A/He and Swiss mice were stimulated to produce red cells at a greater than normal rate through the use of a high altitude chamber. The response to stimulation both before irradiation and after irradiation was examined and compared with that shown by simultaneously irradiated but unstimulated control animals. The mice were maintained at a normal atmosphere for about 3 hours after irradiation in the case of the postirradiation stimulation and for 3 days prior to irradiation in the case of the preirradiation stimulation. The effect of postirradiation stimulation was tested at 700 and 775 R. The poststimulated mice demonstrated poorer survival than the unstimulated controls. These doses were 100 percent lethal at 30 days to both groups, however the mean survival time of the irradiated, stimulated mice was shorter than that of irradiated, unstimulated controls, 4.9 days versus 5.9 days respectively at 775 R, and 5.9 days versus 7.4 days at 700 R. In contrast, mice which were previously erythropoietically stimulated by 3 weeks continuous exposure to one-half atmosphere exhibited a markedly better postirradiation survival than did the unstimulated controls. The effect of preirradiation stimulation was tested at 675 R, 725 R and 775 R. Increased 30- day survival of the prestimulated animals over that of the untreated controls was found at all doses.


Descriptors :   *RADIATION EFFECTS, X RAYS, HYPOXIA, SURVIVAL(PERSONNEL), RADIOBIOLOGY, RADIATION DOSAGE, ANTIBIOTICS, STIMULATION(PHYSIOLOGY), ERYTHROCYTES


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE