Accession Number : AD0672894


Title :   MONKEY (MACACA MULATTA) SURVIVAL TIMES AFTER PULSED GAMMA-NEUTRON IRRADIATION,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Turbyfill,C. L. ; Pitchford,T. L. ; Cramer,M. B.


Report Date : APR 1968


Pagination or Media Count : 26


Abstract : Fifty monkeys (Macaca mulatta) were irradiated at midline tissue doses of 405 to 1540 rads of pulsed gamma-neutron radiations from a TRIGA reactor. The study was performed to obtain lethality data and to record the clinical behavior of the monkey in this dose range. At doses of 500 rads or less, most of the deaths could be attributed to hematopoietic damage, although some animals displayed evidence of gastrointestinal involvement. Survival time was found to be independent of dose in the range of 800 to 1500 rads where deaths appeared due to gastrointestinal injury. A survival-time curve for doses ranging from 336 to 73,000 rads was completed by combining these data with results of previous studies at the AFRRI. From the combined survival-time curve, survival times in the monkey consistent with the CNS syndrome predominate at doses of 4300 rads and above. Postirradiation observations including weight change, food and water consumption, vomiting, diarrhea, and necropsy findings are discussed. (Author)


Descriptors :   *RADIATION INJURIES, SURVIVAL(PERSONNEL), RADIATION DOSAGE, HEMATOPOIETIC SYSTEM, GASTROINTESTINAL SYSTEM, CENTRAL NERVOUS SYSTEM, BODY WEIGHT, INGESTION(PHYSIOLOGY), EMESIS, DIARRHEA, BIOPSY, LETHAL DOSAGE, GAMMA RAYS.


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE