Accession Number : AD0672739


Title :   EFFECTIVENESS OF DRUGS IN ANIMALS EXPOSED TO MIXED GAMMA-NEUTRON RADIATIONS. I. HYPOGLYCEMIC AGENTS,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Davis,L. W. ; Brown,J. A. ; Strike,T. A.


Report Date : MAY 1968


Pagination or Media Count : 24


Abstract : The effect of 200, 1000 and 5000 rads of mixed gamma-neutron radiations on total blood reducing sugar and blood glucose levels in guinea pigs was investigated at 2 and 24 hours, 9, 22 and 60 days postirradiation. In addition, the effectiveness of insulin and tolbutamide was evaluated before and after these doses of radiation. Glucose increased to a lesser degree and later than did the nonglucose fraction of the blood sugar. Insulin and tolbutamide were effective following irradiation except after 5000 rads, when tolbutamide was significantly less effective. These results suggest: (1) insufficient insulin is released by the pancreas in response to elevated blood sugar levels following irradiation, (2) the pancreas does produce insulin at these times and is able to release it in response to tolbutamide, and (3) a decrease in insulin production occurs following supralethal doses of radiation. (Author)


Descriptors :   *HYPERGLYCEMIA, *RADIATION EFFECTS, *DRUGS, RADIATION EFFECTS, INSULIN, RADIATION DOSAGE, GAMMA RAYS, NEUTRONS, BLOOD, GLUCOSE, PANCREAS, SECRETION, LETHAL DOSAGE, RADIOBIOLOGY.


Subject Categories : RADIOBIOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE