Accession Number : AD0641569


Title :   EFFECT OF DIFFERENT INERT GASES AND LOW PRESSURE NORMOXIC ENVIRONMENTS ON OXYGEN UPTAKE IN MICE.


Descriptive Note : Final rept., Nov 64-Jan 66,


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX


Personal Author(s) : Pepelko,William E.


Report Date : OCT 1966


Pagination or Media Count : 11


Abstract : Exposure of adult male Swiss albino mice to air at 28C., ground level pressure, for 24 hours resulted in an oxygen uptake of 78.0 ml./hr. (STPD) as compared with 77.4 ml./hr. in 100% oxygen, 77.7 ml./hr. in 80% Ar:20% O2, and 84.2 ml./hr. in 80% He:20% O2. The increase in oxygen consumption in He:O2 at this temperature approached significance (P < .10). With another group of mice, oxygen consumption during 3-hour exposures to 80% He:20% O2 at 32C. was 88.5 ml./hr. as compared with 90.2 ml./hr. in air. These differences were not significant. With a third group of mice, exposure to 100% oxygen at 226 mm. Hg (absolute) at 28C. for 3 hours resulted in an oxygen consumption of 89.7 ml/hr. as compared with 88.8 ml./hr. in air at ground level pressure. Differences again were not significant. It was concluded that the metabolic stimulating effect of helium at 28C. was a result of its high thermal conductivity, and at 32C. (skin temperature) this effect was no longer apparent. Changes in barometric pressure had no effect on oxygen consumption. (Author)


Descriptors :   (*RARE GASES, METABOLISM), OXYGEN CONSUMPTION, BAROMETRIC PRESSURE, LOW PRESSURE, BODY TEMPERATURE, HIGH ALTITUDE, THERMAL CONDUCTIVITY, MICE


Subject Categories : STRESS PHYSIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE