Accession Number : AD0351962


Title :   THE HUMAN ASSESSMENT OF EA 1729 AND EA 3528 BY THE INHALATION ROUTE


Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD


Personal Author(s) : Ketchum, James S ; Aghajanian, George K ; Bing, Oscar H L


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/351962.pdf


Report Date : Jul 1964


Pagination or Media Count : 51


Abstract : A study of the inhalation effectiveness of agent EA 1729 (d-lysergic acid diethylamide) and its maleate salt was conducted in which retained doses ranging from 0.3 to 7.8 micron g/kg were administered to 60 military volunteers. Onset time for the effective aerosol dose is about 15 min, peak time about 1-1/2 hr, and partial recovery time about 5-1/2 hr. Full recovery requires at least 12 hr. The safety factor in man cannot be stated with certainty. If man resembles most other animals in his toxicological response, the ratio of lethal to effective dose would be very high; however, there is not direct information about lethality in man. By the aerosol dissemination technique employed the effectiveness of the aerosol route is 0.25 to 0.30 that of the oral or intravenous routes. Prior exposure to the agent does not significantly influence the numerical facility performance decrement observed when an equivalent dose is given 2 weeks later.


Descriptors :   *TOXICOLOGY , *LETHAL DOSAGE , *LYSERGIC ACIDS , LABORATORIES , RESPIRATION , DOSAGE , PERFORMANCE(HUMAN) , RECOVERY , PATHOLOGY


Subject Categories : Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE